House diagnoses Mark, Stacy’s husband, and although the tests do not indicate a condition and Mark claims to be fine outside of stomach pain, it appears his brain is dying, leaving House puzzled. When he comes to a potential diagnosis, he has to fight against Mark’s wishes to get the proper test done.





House receives a visit from an ex-girlfriend, Stacy Warner, who seeks his help for her husband. Cuddy forces House to give a lecture to medical students on diagnosing patients and presents three scenarios, each with different reasons for their leg pain (with guest star Carmen Electra).





The teaching hospital buzzes with rumors of House’s upcoming date with Cameron. After House is harsh to an awaiting clinic patient (guest star John Cho), the man develops a mysterious stroke. At the same time, House also deals with an elderly couple whose overactive sex life causes them problems.





House fights off a meningitis outbreak and Cuddy gives his team an hour to produce results after he singles out a young patient who does not quite fit the criteria. House tries to get Cameron to return in the wake of Vogler’s departure, but she demands House tell her why he really wants her back.





A pregnant woman arrives at the hospital with brain and kidney problems and House must contend with her condition and Vogler’s eagerness to see the doctor removed by using the board members. The patient and her husband must decide between her life and their unborn child’s, after the team discovers small cell lung cancer.





A popular U.S. senator and presidential candidate succumbs to illness at a fundraiser and Vogler assigns House to his case. He also tells House he can keep his whole team if he endorses Vogler’s pharmaceutical company. The Senator’s initial diagnosis seems to point to AIDS, but House digs deeper for another answer. Meanwhile, he also handles a case of a woman who apparently gets pregnant without having sex.





House and his team investigate an overweight ten-year-old girl who has a heart attack. Adding to his stress, Vogler demands House get rid of a member of his team.





House is placed under a court order to determine what is ailing a mobster due for federal testimony and the Witness Protection Program. The witness’s brother, a lawyer, works against the team and the testimony when his brother is diagnosed with Hepatitis C. Cuddy continues to battle Vogler over House’s importance to the hospital.





Billionaire entrepreneur Edward Vogler donates $100 million to Princeton-Plainsboro and becomes the new Chairman of the Board. Vogler intends to turn the clinic into a profitable venue for his biotech venture and plans to eliminate House’s financially draining department. Meanwhile, a businesswoman has it all – perfect life, perfect body, perfect job – until she finds herself inexplicably paralyzed. When he diagnoses her condition, House must risk his job and his medical license to save her.





After consulting a Ouija board, a young boy believes he is going to die, and is sent to Princeton-Plainsboro after suffering from pneumonia. Dr. Chase’s estranged father (guest star Patrick Bauchau) comes to the hospital and helps House diagnose the kid.