When House and his team are working on the diagnosis of a man with a swollen tongue, the husband of a former patient walks into House’s office and shoots him. House continues to treat his patient from his ICU bed with the shooter (guest star Elias Koteas), who is shot by hospital security and handcuffed to his bed, as his roommate. When the after effects of the shooting begin to impact House, he starts to question his own ability to diagnose properly. As his patient’s body deteriorates, House struggles through self-doubt and must trust his team to find a way to solve the case.





A 16 year-old Hurricane Katrina victim suffering from horrifying hallucinations is brought to House by a former bandmate who recently discovered the girl is his daughter. Although House fears his friend is being scammed, he takes the case. As he works his way through the girl’s lies in order to diagnose and treat her, he is forced to tell a few lies of his own.





On his way out the door, a man vomits and decides to stay home from work, only to find his wife in the bathtub having a seizure and their newborn infant drowning.





With the police officer dead and fearing for his life, Foreman contacts his father who rushes to his son’s side. Meanwhile, House and the rest of the team are still trying to do everything they can to help Foreman.





House is trying to cure a crooked cop who acts turbulent and laughs uncontrollably, but he and his team are unable to determine the cause. When Foreman starts showing similar symptoms, the situation gets far worse than anybody expected.





House wants to call a 15-year-old faith healer’s bluff, but when the boy is admitted into the hospital he seemingly causes a cancer patient’s condition to go into remission. After being diagnosed, the boy refuses brain surgery, but when his condition worsens, House and his staff have to make a decision.





A young woman’s health becomes a question of ethics when she is unable to sleep for ten days. It is not until House discovers she will need a liver transplant that he also uncovers some vital information about her and her partner Max. Meanwhile, Cameron accuses Foreman of plagiarism when an article he authors appears remarkably similar to one of hers.





The hospital is hosting an oncology benefit poker tournament when a six year-old boy is brought in exhibiting symptoms identical to those of a patient House had twelve years ago. House is convinced the boy’s case is identical and he can predict the course of the young patient’s illness, which ended in the first patient’s death.





Melinda (guest star Michelle Trachtenberg), a troubled teenager who is immuno-compromised as a result of medications she must take after a heart transplant, has a severe allergic reaction and goes into shock when her boyfriend visits her. Meanwhile, House and Wilson continue to work out the problems in their new living arrangement.





When a man cannot breathe during sexual role playing with his wife, House questions the motives behind their marriage; Wilson’s presence in his house begins to take a toll on him.