House and the team take on the case of a young woman who, along with her husband, is rescued at sea en route from Cuba in a desperate attempt to personally see House and get a diagnosis for her illness. During her stay in the hospital, she develops a new symptom: her heart stops – but she miraculously keeps talking. Foreman prepares for his last day at Princeton-Plainsboro Teaching Hospital.





House meets his match in the form of Nathan Harrison, an obnoxious 16 year-old chess prodigy with intense head pain and behavioral issues, who manages to annoy and offend every member of the team during his course of treatment. Meanwhile, Foreman’s frustration with House reaches a new level when he believes House sabotages his job interview with another hospital.





peculation over Foreman’s resignation continues, while a young girl named Addie is admitted after bleeding from the mouth during martial arts practice and House and Wilson are secretly concerned about each other.





A 14 year-old leukemia patient’s only hope of survival is a bone marrow transplant from his younger brother, but when he gets sick, the team must race against time to save both sibilings. Meanwhile, Foreman must deal with the consequences of the previous case.





A scam artist loses her ability to make decisions. While House and the team struggle to find the underlying cause, the case becomes personal for Foreman.





A six year-old girl suffers ailments expected in much older patients. Tensions mount between Chase and Cameron, leading House to intentionally assign them to the same tasks, including investigating the young girl’s home, where they find something possibly incriminating on the girl’s father.





House and Cuddy face a widespread outbreak on their plane back from a symposium in Singapore, while Wilson and the rest of the team treat a woman with constant seizures.





A famous, pregnant photographer, Emma Sloan, is brought to the hospital after suffering a stroke in the middle of a photo shoot. Although Emma’s condition initially stabilizes, her health takes a turn for the worse when her kidneys fail and Emma is more concerned about her baby’s well-being than her own. Meanwhile, the secret relationship between Cameron and Chase is exposed to Foreman and Cuddy, and House makes extravagant plans to take a much-needed vacation.



House treats a U.S. Marine returning from Iraq, who has symptoms consistent with Gulf War Syndrome. However, following a dream about the Marine, the case becomes more complicated, alongside a physical problem that House has to overcome.

A brain-damaged musical savant (guest star Dave Matthews) has seizures despite being on anti-seizure medications. When everyone learns that House has entered himself for brain cancer treatment, they attempt to comfort him, but House simply turns them away.