Clues inside House’s head hold the key to a patient’s condition, and House’s friendship with Wilson is tested beyond limits as murky memories from the bus accident the night before threaten to change their lives forever.





House finds himself dazed, confused and covered in blood after surviving a bus accident that left dozens seriously injured. Unable to clearly recall the events leading up to the crash due to his head injuries, House is convinced through his flashbacks a fellow bus passenger is exhibiting signs of a deadly illness prior to the crash. Much to the team’s dismay, House pushes through the pain of his injuries, desperate to piece together the fragments of his shattered memory in order to save someone who might not even know they could be dying.





House is convinced one of the actors on his favorite soap opera (guest star Jason Lewis) has a serious medical condition, after observing his symptoms on television. He decides to intervene and take matters into his own hands, but both the actor and House’s team dismiss his assessment and do not believe there is anything wrong. Meanwhile, Wilson and his girlfriend have their first argument and Cuddy tries to keep up appearances when an inspector makes an unexpected visit to Princeton-Plainsboro.





House suspects an emergency room patient has a bigger problem than the E.R. initially diagnosed based on the fact that the patient is too nice. A skeptical House questions the patient’s sunny disposition as the team tries to get to the bottom of his illness, but disagrees with House that niceness is a symptom. Meanwhile, House is at odds with Wilson’s girlfriend about how much time they each get to spend with Wilson, and Cuddy demands House give his team performance reviews.





House and the team encounters a woman (guest star Laura Silverman) admitted to Princeton-Plainsboro after she collapses at her wedding. Her test results come up negative for a variety of common diseases, which leads the team to suspect foul play, but when they discover the woman is a former music producer living in the fast lane until she began to practice Hasidic Judaism, House insists people do not change, and her seemingly rash decision may be a symptom of the underlying condition.





When Dr. Cate Milton (guest star Mira Sorvino), a psychiatrist trapped in the South Pole and the research station’s only doctor, becomes ill in the middle of her assignment, she and House are thrust into a long-distance relationship of sorts. Unable to get Cate out or any additional medical supplies to the South Pole station, House and his team must resort to treating her via webcam. Meanwhile House sends Taub, Kutner and Thirteen to harass Cameron until she gets cable for his office, and he attempts to discover Wilson’s new girlfriend (Amber).





House and the team treat a woman who suffers from a sudden paralysis of the hands, causing an injury to her daughter while she is watching her at an indoor rock-climbing wall. As House probes the woman and her injured daughter for any leads as to what might be causing her condition, he is convinced the mother is withholding information.





House assigns the candidates to a particularly challenging case involving an uncooperative punk guitarist with a history of drug abuse and civil disobedience, while Cuddy orders House to make a final decision and hire his new team. House promises a guaranteed position for the candidate who correctly diagnoses the patient. Meanwhile, Wilson informs a former patient he misdiagnosed him with terminal cancer and is now going to live and must deal with the consequences of his procedures.





House encounters a magician whose heart fails when performing an underwater escape act. While the remaining fellowship candidates work to diagnose him, House is determined to prove he is a scam artist faking his ailments to cover up the fact he nearly drowned during his act. In the meantime, House pits his team against one another in a challenge involving Cuddy, granting the winner immunity from elimination and a chance to nominate two other candidates to be put on the chopping block.





House and his team are followed by a documentary film crew as they treat a teenager with a major facial deformity, who suffers a heart attack prior to a reconstructive procedure. As they work to diagnose the teen, House finds himself distracted by several of the candidates vying for a spot on his team, causing him to question his own motives for having chosen them.